Drug Metab Lett. 2008 Dec;2(4):261-8. -
Identification of four urea adducts of andrographolide in humans.
Cui L, Chan W, Qiu F, Cai Z, Yao X.
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.
Publication Types:- Clinical Trial
PMID: 19356103 [PubMed - indexed for MEDLINE]
Identification of four urea adducts of andrographolide in humans
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