Sulaiman MR, Zakaria ZA, Abdul Rahman A, Mohamad AS, Desa MN, Stanslas
J, Moin S, Israf DA.
The current study was performed to evaluate the antinociceptive and
antiedematogenic properties of andrographolide isolated from the
leaves of Andrographis paniculata using two animal models.
Antinociceptive activity was evaluated using the acetic acid-induced
writhing and the hot-plate tests, while antiedematogenic activity was
measured using the carrageenan-induced paw edema test. Subcutaneous
(s.c.) administration of andrographolide (10, 25, and 50 mg/kg) did
not affect the motor coordination of the experimental animals but
produced significant (p < .05) antinociceptive activity when assessed
using both tests. However, 2 mg/kg naloxone failed to affect the 25
mg/kg andrographolide activity in both tests, indicating that the
activity was modulated via nonopioid mechanisms. Furthermore,
andrographolide showed significant (p < .05) antiedematogenic
activity. In conclusion, the results obtained suggest that
andrographolide has antinociceptive and antiedematogenic activities;
it may be useful for treating pain and inflammation once human studies
are conducted.
PMID: 19689990 [PubMed - as supplied by publisher]
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