Trivedi NP, Rawal UM, Patel BP.
Department of Zoology, School of Sciences, Gujarat University, India.
RELEVANCE: The present investigation relates to the influence of
andrographolide, an active compound of Andrographis paniculata Nees.
It reverses an experimental liver carcinogenic condition of mice to
normal and might be a potential therapeutic/preventive agent for human
liver cancer. OBJECTIVE: A. paniculata (Kalmegh) is extensively used
in the Indian traditional system of medicine as a hepatoprotective and
hepatostimulative agent and has been reported to have protective
effect against different hepatotoxins. MATERIALS AND METHODS:
Histomorphological, ultrastructural, and biochemical studies were
performed for the effect of the andrographolide on control mice, mice
treated with hexachlorocyclohexane (BHC) only and BHC +
andrographolide. Enzymes for liver function tests were analyzed by
spectrophotometric method. RESULTS: The BHC experimental model forms
an irreversible liver tumor in male mice. The histological and
ultrastructural changes observed in andrographolide supplementation
emphasize the recovery of the damaged liver. This recovery was also
reflected in the neoplastic nodule formation. The activity of
phosphorylase and glucose-6-phosphatase in the liver of the
andrographolide-supplemented group suggests improved glycogenolysis in
liver. Serum glutamate pyruvate transaminase, serum glutamate oxalate
transaminase, alkaline phosphatase, acid phosphatase, and
gamma-glutamyl transpeptidase showed a significant decrease in
andrographolide-supplemented animals as compared with BHC-treated
animals, suggesting regenerative effects elicited by andrographolide.
CONCLUSION: The study indicates that the regenerative capability
elicited by andrographolide is possibly due to its ability to
reactivate liver function enzymes that catalyze the reaction of
several biochemical and synthetic processes and that it may be useful
for severe liver damage conditions.
Publication Types:
Research Support, Non-U.S. Gov't
PMID: 19679627 [PubMed - in process]
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