Singh P, Srivastava MM, Khemani LD.
Department of Chemistry, Dayalbagh Educational Institute (Deemed
University), Agra, India.
Background. Renal failure is an increasingly common condition with
limited treatment options that is causing a major financial and
emotional burden on the community. Andrographis paniculata is the
plant used in Ayurveda for several remedies. Scientific evidence
suggests its versatile biological functions that support its
traditional use in the Orient. The plant is claimed to possess
immunological, antibacterial, anti-inflammatory, antithrombotic, and
hepatoprotective properties. But, to date, there is no study
demonstrating the protective effect of A. paniculata on
gentamicin-induced renal failure. The present study aims to highlight
the first ever reported, antirenal failure activity of A. paniculata.
Methods. Male Wistar albino rats were divided into three groups:
normal control, gentamicin control, and aqueous extract of A.
paniculata (200 mg/kg, per oral (p.o.))-treated. The nephrotoxic model
was induced by gentamicin (80 mg/kg, intraperitoeal (i.p.)). Blood
samples were examined for serum creatinine, serum urea, and blood urea
nitrogen after the 10 days of treatment. Results. A gentamicin-induced
nephrotoxic animal model was successfully prepared. Aqueous extract of
A. paniculata attenuated the gentamicin-induced increase in serum
creatinine, serum urea, and blood urea nitrogen levels by 176.92%,
106.27%, and 202.90%, respectively. Conclusion. The present study
reports that the aqueous extract (whole plant) of A. paniculata (Burm.
f.) Nees exhibits a significant renoprotective effect in
gentamicin-induced nephrotoxicity in male Wistar albino rats.
PMID: 19736602 [PubMed - in process]
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