Applied Entomology and Zoology
Vol. 36 (2001) , No. 1 143-149
[PDF (63K)] [References]
Efficacy of plant extracts for reducing larval populations of the diamondback moth, Plutella xylostella L. (Lepidoptera: Yponomeutidae) and cabbage webworm, Crocidolomia binotalis Zeller (Lepidoptera: Pyralidae), and evaluation of cabbage damage
Dadang1) and Kanju Ohsawa2)
1) Department of Plant Pests and Diseases, Faculty of Agriculture, Bogor University of Agriculture
2) Division of Bioregulation Studies, Graduate School of Agriculture, Tokyo University of Agriculture
(Received February 24, 1999) (Accepted October 16, 2000)
Abstract
The efficacy of four plant extracts, Alpinia galanga Sw. (Zingiberaceae), Amomum cardamomum Auct. (Zingiberaceae), Cyperus rotundus L. (Cyperaceae), and Gomphrena globosa L. (Amaranthaceae) were evaluated against the diamondback moth, Plutella xylostella L. and the cabbage webworm Crocidolomia binotalis Zeller larvae on cultivated cabbage. Treatments with 0.5% A. galanga and G. globosa extracts significantly reduced P. xylostella larval density, and the percentage of infested plants, proving to be more effective than a standard insecticide Decis7 2.5EC (deltamethrin). Moreover, G. globosa significantly reduced the intensity of cabbage damage caused by P. xylostella. Treatment with 0.5% A. cardamomum extract reduced the percentage of P. xylostella-infested plants and the intensity of cabbage damage. However, the plant extracts did not effectively reduce C. binotalis larval density, the percentage of infested plants or the intensity of cabbage damage. Phytotoxic effects on cabbage plants were not observed in any extract treatment.
Key words: plant extracts, field efficacy, Plutella xylostella, Crocidolomiano bitalis
[PDF (63K)] [References]
To cite this article:
Dadang and Kanju Ohsawa: “Efficacy of plant extracts for reducing larval populations of the diamondback moth, Plutella xylostella L. (Lepidoptera: Yponomeutidae) and cabbage webworm, Crocidolomia binotalis Zeller (Lepidoptera: Pyralidae), and evaluation of cabbage damage” Applied Entomology and Zoology Vol. 36, pp.143-149 (2001)
Strong synergistic induction of CYP1A1 expression by andrographolide
1: Toxicol Appl Pharmacol. 2007 Jul 28; [Epub ahead of print]
Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes.
Jaruchotikamol A, Jarukamjorn K, Sirisangtrakul W, Sakuma T, Kawasaki Y, Nemoto N.
Department of Toxicology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
The effects of andrographolide, the major diterpenoid constituent of Andrographis paniculata, on the expression of cytochrome P450 superfamily 1 members, including CYP1A1, CYP1A2, and CYP1B1, as well as on aryl hydrocarbon receptor (AhR) expression in primary cultures of mouse hepatocytes were investigated in comparison with the effects of typical CYP1A inducers, including benz[a]anthracene, beta-naphthoflavone, and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Andrographolide significantly induced the expression of CYP1A1 and CYP1A2 mRNAs in a concentration-dependent manner, as did the typical CYP1A inducers, but did not induce that of CYP1B1 or AhR. Interestingly, andrographolide plus the typical CYP1A inducers synergistically induced CYP1A1 expression, and the synergism was blocked by an AhR antagonist, resveratrol. The CYP1A1 enzyme activity showed a similar pattern of induction. This is the first report that shows that andrographolide has a potency to induce CYP1A1 enzyme and indicates that andrographolide could be a very useful compound for investigating the regulatory mechanism of the CYP1A1 induction pathway. In addition, our findings suggest preparing advice for rational administration of A. paniculata, according to its ability to induce CYP1A1 expression.
PMID: 17825862 [PubMed - as supplied by publisher]
Antioxidant action of Andrographis paniculata
1: Mol Biol Rep. 2007 Sep 5; [Epub ahead of print] Related Articles
Antioxidant action of Andrographis paniculata on lymphoma.
Verma N, Vinayak M.
Biochemistry & Molecular Biology Lab, Department of Zoology, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India, manjulavinayak@rediffmail.com.
Regulation of the balance between production of reactive oxygen species (ROS) by cellular processes and its removal by antioxidant defense system maintains normal physiological processes. Any condition leading to increased ROS results in oxidative stress which has been related with a number of diseases including cancer. Improvement in antioxidant defense system is required to overcome the damaging effects of oxidative stress. Therefore in the present study, effect of the aqueous extract of a medicinal plant Andrographis paniculata (AP) on antioxidant defense system in liver is investigated in lymphoma bearing AKR mice. Estimating catalase, superoxide dismutase and glutathione S transferase monitored the antioxidant action. Oral administration of the aqueous extract of A. paniculata in different doses causes a significant elevation of catalase, superoxide dismutase and glutathione S transferase activities. It reveals the antioxidant action of the aqueous extract of AP, which may play a role in the anticarcinogenic activity by reducing the oxidative stress. LDH activity is known to increase in various cancers due to hypoxic condition. Lactate dehydrogenase is used as tumor marker. We find a significant decrease in LDH activity on treatment with AP, which indicates a decrease in carcinogenic activity. A comparison with Doxorubicin (DOX), an anticancerous drug, indicates that the aqueous extract of AP is more effective than DOX with respect to its effect on catalase, superoxide dismutase, glutathione S transferase as well as on lactate dehydrogenase activities in liver of lymphoma bearing mice.
PMID: 17805989 [PubMed - as supplied by publisher]
Hepatoprotective effect of andrographolide
1: Integr Cancer Ther. 2007 Sep;6(3):271-80.
Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury.
Trivedi NP, Rawal UM, Patel BP.
Department of Zoology, School of Sciences, Gujarat University, Ahmedabad, India.
Many plant products are known to exert antioxidative effects by quenching various free radicals and singlet molecular oxygen. Andrographis paniculata (Kalmegh) is used extensively in the Indian traditional system of medicine as a hepatoprotective and hepatostimulative agent and has been reported to have antioxidant effects against different hepatotoxins. The present study aims to analyze antioxidant properties of an active component, andrographolide (ANDLE), extracted from A paniculata. This study investigates the effect of andrographolide on the hepatocellular antioxidant defense system and lipid peroxidation of control mice, mice treated with hexachlorocyclohexane (BHC) only, and andrographolide + BHC. Glutathione (GSH), glutathione-s-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GSH-Px), gamma-glutamyl transpeptidase (gamma-GTP), superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation (LPO) are studied by spectrophotometric methods. The BHC experimental model forms an irreversible liver tumor in male mice. The activities of GSH, GR, GSH-Px, SOD, and CAT show significant (P </= .05) increases, while gamma-GTP and GST show significant decreases (P </= .05) in andrographolide-supplemented mice as compared with BHC-treated mice. This study indicates that the antioxidant effect of andrographolide could be due to its ability to activate antioxidant enzymes that catalyze the reaction of oxidants and are effective in severe liver damage.
PMID: 17761640 [PubMed - in process]
2: Phytother Res. 2007 Aug 17; [Epub ahead of print] Related Articles, LinkOut 
Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats.
Sangameswaran B, Reddy TC, Jayakar B.
Vinayaka Mission's College of Pharmacy, Vinayaka Missions University, K.N. Patty, Salem-636 008, Tamil Nadu, India.
The present study was conducted to evaluate the hepatoprotective effect of Andrographis lineata (Acanthaceae) extracts in carbon tetrachloride-induced liver injury in rats. Male Wistar rats with chronic liver damage, induced by subcutaneous injection of 50% v/v carbon tetrachloride in liquid paraffin at a dose of 3 mL/kg on alternate days for a period of 4 weeks, were treated with methanol and aqueous extracts of A. lineata orally at a dose of 845 mg/kg/day. The biochemical parameters such as serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum bilirubin and alkaline phosphatase were estimated to assess the liver function. Histopathological studies of the liver were also carried out to confirm the biochemical changes. Histopathological examinations of liver tissue corroborated well with the biochemical changes. The activities of extracts were comparable to a standard drug. Hepatic steatosis, hydropic degeneration and necrosis were observed in the carbon tetrachloride treated group, while these were completely absent in the standard and extract treated groups. A. lineata extracts exhibited hepatoprotective action against carbon tetrachloride-induced liver injury. The present investigation established pharmacological evidence to support the folklore claim that it is used traditionally as a hepatoprotective agent. Copyright (c) 2007 John Wiley & Sons, Ltd.
PMID: 17705141 [PubMed - as supplied by publisher]
3: Anticancer Res. 2007 Jul-Aug;27(4B):2439-47. Related Articles, LinkOut
Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression.
Jiang CG, Li JB, Liu FR, Wu T, Yu M, Xu HM.
Department of Oncology, The First Affiliated Hospital, Shenyang, Liaoning Province, China.
BACKGROUND: Andrographolide, an active component isolated from the Chinese official herbal Andrographis paniculata, has recently been reported to have anticancer activity. However the molecular mechanism responsible for its anticancer action has not been fully defined. In this study, we investigated the effect of andrographolide on the adhesion of gastric cancer cells to the activated endothelial cells and the expression of some cell adhesion molecules. MATERIALS AND METHODS: Human endothelial cells were preincubated with andrographolide for 6 h and then incubated with the cytokine tumor necrosis factor for 4 h. Endothelial surface expression of E-selectin was evaluated by flow cytometry, immunostaining and ELISA. Further, we investigated E-selectin mRNA expression by RT-PCR. Surface expression of sialyl Lewis(X) of three gastric cancer cell lines (SGC7901, MGC803, BGC823) and a normal gastric epithelial cell line GES-1 was evaluated by flow cytometry and immunostaining. Adherence of CFSE-labeled gastric cancer cells and GES-1 cells to endothelial cell monolayers was then determined. RESULTS: Andrographolide significantly reduced E-selectin expression of activated endothelial cells, and inhibited the E-selectin expression on mRNA level. Three gastric cancer cell lines expressed high levels of sialyl Lewis(X), whereas GES-1 did not. Andrographolide also significantly decreased gastric cancer cells adherence to stimulated endothelial cells. The inhibition of E-selectin expression corresponded to the reduction of tumor cell adherence. The effects of andrographolide on tumor adhesion were almost nullified by pre-incubation with E-selectin and sialyl Lewis(X) antibody. CONCLUSION: These findings demonstrate that andrographolide suppresses the adhesion of gastric cancer cells which express high level sialyl Lewis(X) to human vascular endothelial cells by blocking E-selectin expression and, thus, may represent a candidate therapeutic agent for cancer.
PMID: 17695536 [PubMed - in process]
4: Zhongguo Zhong Yao Za Zhi. 2006 Jun;31(12):1015-7. Related Articles, Compound via MeSH, Substance via MeSH, LinkOut
[Effect of andrographolide on QS regulating virulence factors production in Pseudomonas aeruginosa]
[Article in Chinese]
Li HT, Qin HM, Wang WH, Li GJ, Wu CM, Song JX.
Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
OBJECTIVE: To investigate the effect of andrographolide on virulence factors production in Pseudomonas aeruginosa. METHOD: Growth rate, pyocyanin, proteolytic activity and elastase activity were measured with or without the presence of andrographolide. The effect of andrographolide on pyocyanin production, proteolytic activity and elastase activity in PAO-JP2 was investigated simultaneously. RESULT: The andrographolide did not affect the growth of PAO1 in planktonic culture. The production of pyocyanin, proteolytic activity and elastase activity were significanthy suppressed in P. aeruginosa cultures grown in the presence of andrographolide. However, these effects were not observed in PAO-JP2. CONCLUSION: The inhibiting effect of andrographolide on virulence factors production in P. aeruginosa may play a role in its anti-infection activity.
Publication Types:- English Abstract
- Research Support, Non-U.S. Gov't
PMID: 17048654 [PubMed - indexed for MEDLINE]
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