Nat Prod Commun. 2010 Jan;5(1):59-60.
Radhika P, Prasad YR, Lakshmi KR.
Department of Biochemistry, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India. parvataneni_radhika@yahoo.com
Chemical investigation of Andrographis paniculata Nees (Acanthaceae) resulted in the isolation of three flavones identified as 5-hydroxy-7,8,2'-trimethoxyflavone 1, 5-hydroxy-7,8-dimethoxyflavone 2 and 5-hydroxy-7,8,2',5'-tetramethoxyflavone 3 from the hexane, methanol and chloroform extracts of the root and stem.
PMID: 20184022 [PubMed - in process]
Indigenous knowledge of medicinal plants used by Saperas community of Khetawas, Jhajjar District, Haryana, India
Ethnobiol Ethnomed. 2010; 6: 4.
Published online 2010 January 28. doi: 10.1186/1746-4269-6-4.
Manju Panghal,#1 Vedpriya Arya,#1 Sanjay Yadav,#1 Sunil Kumar,#2 and Jaya Parkash Yadavcorresponding author#1
1Department of Genetics, M.D. University Rohtak, Haryana, India
2Department of Environment Science, M.D. University Rohtak, Haryana, India
corresponding authorCorresponding author.
#Contributed equally.
Abstract
Background
Plants have traditionally been used as a source of medicine in India by indigenous people of different ethnic groups inhabiting various terrains for the control of various ailments afflicting human and their domestic animals. The indigenous community of snake charmers belongs to the 'Nath' community in India have played important role of healers in treating snake bite victims. Snake charmers also sell herbal remedies for common ailments. In the present paper an attempt has been made to document on ethno botanical survey and traditional medicines used by snake charmers of village Khetawas located in district Jhajjar of Haryana, India as the little work has been made in the past to document the knowledge from this community.
Methods
Ethno botanical data and traditional uses of plants information was obtained by semi structured oral interviews from experienced rural folk, traditional herbal medicine practitioners of the 'Nath' community. A total of 42 selected inhabitants were interviewed, 41 were male and only one woman. The age of the healers was between 25 years and 75 years. The plant specimens were identified according to different references concerning the medicinal plants of Haryana and adjoining areas and further confirmation from Forest Research Institute, Dehradun.
Results
The present study revealed that the people of the snake charmer community used 57 medicinal plants species that belonged to 51 genera and 35 families for the treatment of various diseases. The study has brought to light that the main diseases treated by this community was snakebite in which 19 different types of medicinal plants belongs to 13 families were used. Significantly higher number of medicinal plants was claimed by men as compared to women. The highest numbers of medicinal plants for traditional uses utilized by this community were belonging to family Fabaceae.
Conclusion
This community carries a vast knowledge of medicinal plants but as snake charming is banned in India as part of efforts to protect India's steadily depleting wildlife, this knowledge is also rapidly disappearing in this community. Such type of ethno botanical studies will help in systematic documentation of ethno botanical knowledge and availing to the scientific world plant therapies used as antivenin by the Saperas community.
Published online 2010 January 28. doi: 10.1186/1746-4269-6-4.
Manju Panghal,#1 Vedpriya Arya,#1 Sanjay Yadav,#1 Sunil Kumar,#2 and Jaya Parkash Yadavcorresponding author#1
1Department of Genetics, M.D. University Rohtak, Haryana, India
2Department of Environment Science, M.D. University Rohtak, Haryana, India
corresponding authorCorresponding author.
#Contributed equally.
Abstract
Background
Plants have traditionally been used as a source of medicine in India by indigenous people of different ethnic groups inhabiting various terrains for the control of various ailments afflicting human and their domestic animals. The indigenous community of snake charmers belongs to the 'Nath' community in India have played important role of healers in treating snake bite victims. Snake charmers also sell herbal remedies for common ailments. In the present paper an attempt has been made to document on ethno botanical survey and traditional medicines used by snake charmers of village Khetawas located in district Jhajjar of Haryana, India as the little work has been made in the past to document the knowledge from this community.
Methods
Ethno botanical data and traditional uses of plants information was obtained by semi structured oral interviews from experienced rural folk, traditional herbal medicine practitioners of the 'Nath' community. A total of 42 selected inhabitants were interviewed, 41 were male and only one woman. The age of the healers was between 25 years and 75 years. The plant specimens were identified according to different references concerning the medicinal plants of Haryana and adjoining areas and further confirmation from Forest Research Institute, Dehradun.
Results
The present study revealed that the people of the snake charmer community used 57 medicinal plants species that belonged to 51 genera and 35 families for the treatment of various diseases. The study has brought to light that the main diseases treated by this community was snakebite in which 19 different types of medicinal plants belongs to 13 families were used. Significantly higher number of medicinal plants was claimed by men as compared to women. The highest numbers of medicinal plants for traditional uses utilized by this community were belonging to family Fabaceae.
Conclusion
This community carries a vast knowledge of medicinal plants but as snake charming is banned in India as part of efforts to protect India's steadily depleting wildlife, this knowledge is also rapidly disappearing in this community. Such type of ethno botanical studies will help in systematic documentation of ethno botanical knowledge and availing to the scientific world plant therapies used as antivenin by the Saperas community.
Gender-associated modulation of inducible CYP1A1 expression by andrographolide in mouse liver
Eur J Pharm Sci. 2010 Jan 28. [Epub ahead of print]
Jarukamjorn K, Kondo S, Chatuphonprasert W, Sakuma T, Kawasaki Y, Nemoto N.
Academic Office for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Khon Kaen University, Mitrapaab Road, Khon Kaen 40002, Thailand.
We previously observed a strong synergistic effect on polycyclic aromatic hydrocarbon (PAH)-induced CYP1A1 expression by andrographolide, a major constituent of an herbal medicine derived from the plant Andrographis paniculata, in mouse hepatocytes in primary culture. The present paper describes confirmation of an enhancing effect of andrographolide on the CYP1 family in vivo in the PAH-responsive C57BL/6 mouse. Andrographolide did not alter CYP1 expression in the PAH-nonresponsive DBA/2 mouse. The enhanced expression induced by andrographolide was observed in male C57BL/6 mice, but not in intact or ovariectomized females, or in orchiectomized male mice. However, treatment with testosterone restored the effect in both orchiectomized males and ovariectomized females. These observations indicate a male hormone-related system to be a crucial mediator of the modulation of CYP1 expression by andrographolide. Precautions should be taken regarding the use of Andrographis paniculata as an alternative medication or health promotion, according to its distinctive characterization on sexually dimorphic modulation of CYP1A1 expression. Copyright © 2010 Elsevier B.V. All rights reserved.
PMID: 20117208 [PubMed - as supplied by publisher]
Jarukamjorn K, Kondo S, Chatuphonprasert W, Sakuma T, Kawasaki Y, Nemoto N.
Academic Office for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Khon Kaen University, Mitrapaab Road, Khon Kaen 40002, Thailand.
We previously observed a strong synergistic effect on polycyclic aromatic hydrocarbon (PAH)-induced CYP1A1 expression by andrographolide, a major constituent of an herbal medicine derived from the plant Andrographis paniculata, in mouse hepatocytes in primary culture. The present paper describes confirmation of an enhancing effect of andrographolide on the CYP1 family in vivo in the PAH-responsive C57BL/6 mouse. Andrographolide did not alter CYP1 expression in the PAH-nonresponsive DBA/2 mouse. The enhanced expression induced by andrographolide was observed in male C57BL/6 mice, but not in intact or ovariectomized females, or in orchiectomized male mice. However, treatment with testosterone restored the effect in both orchiectomized males and ovariectomized females. These observations indicate a male hormone-related system to be a crucial mediator of the modulation of CYP1 expression by andrographolide. Precautions should be taken regarding the use of Andrographis paniculata as an alternative medication or health promotion, according to its distinctive characterization on sexually dimorphic modulation of CYP1A1 expression. Copyright © 2010 Elsevier B.V. All rights reserved.
PMID: 20117208 [PubMed - as supplied by publisher]
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