Allan JJ, Pore MP, Deepak M, Murali B, Mayachari AS, Agarwal A.
MVSc, Department of Pharmacology and Toxicology, R&D Centre, Natural
Remedies Pvt Ltd, 5B, Veerasandra Industrial Area, 19th KM Stone,
Hosur Road, Near Electronic City, Bangalore 560 100, India;
joshua@naturalremedy.com.
The possible effect of extract of Andrographis paniculata Nees (A
paniculata) standardized to >/=10% andrographolide, the main bioactive
component, on male fertility in albino Wistar rats was evaluated, by
orally administering 0, 20, 200, and 1000 mg/kg of body weight per
day, for 65 days prior to mating and 21 days during mating. The
treated groups showed no signs of dose-dependent toxicity. The body
weight gain and feed consumption were not affected at any of the dose
levels. The testosterone levels and fertility indices in treatment
groups were found to be comparable with that of the control indicating
no effect on fertility. Total sperm count and sperm motility were not
affected. The testes and epididymides did not show any gross and
histopathological changes. Based on these findings, it can be
concluded that the no-observed adverse effect level of extract of A
paniculata (>/=10% andrographolide) was found to be more than 1000
mg/kg per day.
PMID: 19636073 [PubMed - in process]
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