Sattayasai J, Srisuwan S, Arkaravichien T, Aromdee C.
Department of Pharmacology, Faculty of Medicine, Khon Kaen University,
Khon Kaen, Thailand.
Abstract
In this study, effects of andrographolide from Andrographis paniculata
on sexual functions, vascular reactivity and serum testosterone level
in experimental animals were observed. The suspension of
andrographolide in 5% DMSO was administered orally at the dose of 50
mg/kg to male ICR mice. The female mice involved in mating were made
receptive by hormonal treatment. The mating behaviors, mounting
latency and mounting frequency, were determined and compared with the
standard reference drug sildenafil citrate. Administration of
andrographolide significantly increased the mounting latency at 120
and 180 min and mounting frequency at 180 min after treatment. In
endothelium-intact rat aortic strips, norepineprine-induced
contraction was reduced by preincubation with andrographolide.
Administration of 50 mg/kg andrographolide orally to male mice once
daily for 2, 4, 6 or 8 weeks had no significant effects on sperm
morphology and motility. Interestingly, at week 4, serum testosterone
level in mice treated with andrographolide was significantly increased
when compared to the control. Thus, the effects of andrographolide on
vascular response to norepinephrine and testosterone level observed in
this study might be contributed to the sexual enhancing properties
observed. Copyright © 2010. Published by Elsevier Ltd.
PMID: 20435079 [PubMed - as supplied by publisher]
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