Pfisterer PH, Rollinger JM, Schyschka L, Rudy A, Vollmar AM, Stuppner H.
Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences
Innsbruck, Leopold-Franzens University of Innsbruck, Innsbruck,
Austria.
Abstract
Extracts of the traditional medicinal herb ANDROGRAPHIS PANICULATA and
its main constituents are described in the literature as showing
anticancer activity. The aim of this study was to isolate the main
constituents of a commercially available phytotherapeutic preparation
of A. PANICULATA and to determine their chemosensitizing potential in
a leukemia cell line. Chromatographic separation steps resulted in the
isolation of the diterpenes andrographolide ( 1) and
14-deoxy-11,12-didehydroandrographolide ( 3) and the diterpene
glucoside neoandrographolide ( 2). The combination of these
constituents with suboptimal concentrations of etoposide revealed
compound 2 as chemosensitizer in S-Jurkat and X chromosome-linked
inhibitor of apoptosis protein (XIAP)-overexpressing Jurkat cells, a
model for chemoresistance. © Georg Thieme Verlag KG Stuttgart · New
York.
PMID: 20446243 [PubMed - as supplied by publisher]
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