Chao WW, Lin BF.
Abstract
ABSTRACT: Andrographis paniculata (Burm. f.) Nees (Acanthaceae) is a
medicinal plant used in many countries. Its major constituents are
diterpenoids, flavonoids and polyphenols. Among the single compounds
extracted from A. paniculata, andrographolide is the major one in
terms of bioactive properties and abundance. Among the andrographolide
analogues, 14-deoxy-11,12-didehydroandrographolide is
immunostimulatory, anti-infective and anti-atherosclerotic;
neoandrographolide is anti-inflammatory, anti-infective and
anti-hepatotoxic; 14-deoxyandrographolide is immunomodulatory and
anti-atherosclerotic. Among the less abundant compounds from A.
paniculata, andrograpanin is both anti-inflammatory and
anti-infective; 14-deoxy-14,15-dehydroandrographolide is
anti-inflammatory; isoandrographolide,
3,19-isopropylideneandrographolide and 14-acetylandrographolide are
tumor suppressive; arabinogalactan proteins are anti-hepatotoxic. The
four flavonoids from A. paniculata, namely 7-O-methylwogonin,
apigenin, onysilin and 3,4-dicaffeoylquinic acid are
anti-atherosclerotic.
PMID: 20465823 [PubMed - as supplied by publisher]
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