Menon V, Bhat S.
Laboratory for Advanced Research in Natural and Synthetic Chemistry,
V. G. Vaze College, Mumbai University, Mithagar road, Mulund (East),
Mumbai 400 081, India.
Andrographolide 1, a diterpene lactone of Andrographis paniculata,
displays in vitro and in vivo antitumor activity against breast cancer
models and mouse myeloid leukemia (M1) cells. In the present study, we
report the semi-synthesis of andrographolide derivatives and their in
vitro activity against A549 (ATCC) (NSCL cancer) cell line. Amongst
the derivatives tested, compounds 3-5 displayed maximum activity, with
IC50 values of 22-31 microg/mL.
PMID: 20521534 [PubMed - in process]
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