Patel CD, Modi VD, Chakraborty BS, Mathuria N, Dadhaniya P, Borade PA,
Morankar P.
The present investigation was an attempt to evaluate the
anti-inflammatory effect of a polyherbal preparation (Sudarshanam Oil)
on hematological parameters in Wistar rats. This polyherbal formula
contains main ingredients of Tinaspora Cordifolia, Curcuma longa,
Terminalia chebula, Emblica officinalis, Andrographis paniculata and
Terminalia belerica. The active phytochemicals such as tannins,
glycosides, flavonoids and triterpenoids are extracted from these
herbal plants. And extract was prepared in corn oil. Young adult
Wistar rats of either sex were divided into 4 groups and each group
having 6 males and 6 females were dosed for 28 days. First group was
the control group which was dosed with corn oil as vehicle (15 mL/kg
body weight). Groups II, III and IV were treated with different doses
of Sudarshanam oil, viz. as 5 mL/kg, 10 mL/kg and 15 mL/kg body weight
respectively. On 29th day, after overnight fasting, the blood samples
were collected through cardiac puncture under CO2 anaesthesia. The
blood samples were collected and transferred into prelabelled
vaccutainer coated with EDTA for hematological parameters
investigation by using Advia-120 hematology analyser. The results
revealed that no treatment related adverse effects in any of the
hematological parameters. Thus, Sudarshanam oil proves to be highly
potent, novel anti-inflammatory preparation which can be a challenge
against allopathic anti-inflammatory drug.
PMID: 20524430 [PubMed - in process]
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