Srivastava N, Akhila A.
Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, India.
Andrographolide, a diterpene lactone, is isolated from Andrographis
paniculata which is well known for its medicinal properties. The
biosynthetic route to andrographolide was studied using
[1-(13)C]acetate, [2-(13)C]acetate and [1,6-(13)C(2)]glucose. The peak
enrichment of eight carbon atoms in the (13)C NMR spectra of
andrographolide suggested that deoxyxylulose pathway (DXP) is the
major biosynthetic pathway to this diterpene. The contribution of the
mevalonic acid pathway (MVA) is indicated by the observed
(13)C-labeling pattern, and because the labeling patterns indicate a
simultaneous contribution of both methyl erythritol phosphate (MEP)
and MVA pathways it can be deduced that cross-talk occurs between
plastids and cytoplasm. Copyright © 2010 Elsevier Ltd. All rights
reserved.
PMID: 20557910 [PubMed - as supplied by publisher]
Posts
